AMELIORATIVE EFFECT OF SIDA CORDIFOLIA L. AGAINST SCOPOLAMINE-INDUCED COGNITIVE DEFICIT MICE MODEL

Evaluation of the effect of Cyperus rotundus L. in scopolamine-induced learning deficit in mice

BACKGROUND Cyperus rotundus L. was used in traditional Iranian medicine to treat memory and cognition disorders. The present study was aimed at investigating the effect of the extract and essential oil of C. rotundus on memory dysfunction. MATERIALS AND METHODS Cognition was evaluated using the object recognition task that was composed of a square wooden open field box with different shape ob...

AM281, Cannabinoid Antagonist/Inverse agonist, Ameliorates Scopolamine-Induced Cognitive Deficit

Objective(s) Cannabinoids have been implicated in memory deficit. We examined the effect of AM281, cannabinoid antagonist/inverse agonist in prevention of scopolamine-induced cognitive deficit. Materials and Methods  Object recognition task was used to evaluate memory in mice. Exploration time in the first and the second trial was recorded. The differences in exploration between a previously...

Effect of resveratrol on scopolamine-induced cognitive impairment in mice.

BACKGROUND Resveratrol (3,4',5-trihydroxystilbene) is a naturally occurring compound found in grapes, wine, peanuts and cranberries. Recently, in vitro and cell culture studies have reported beneficial effects of resveratrol in the neurodegenerative process in Alzheimer's disease (AD). However, in vivo effect of resveratrol in models of learning and memory is not yet evaluated. The present stud...

evaluation of the effect of cyperus rotundus l. in scopolamine-induced learning deficit in mice

Cognitive-Enhancing Effect of Aronia melanocarpa Extract against Memory Impairment Induced by Scopolamine in Mice

Aronia melanocarpa (A. melanocarpa) berries are a fruit with a marked antioxidant effect. The objective of this study was to confirm the effect of A. melanocarpa berries extract against scopolamine-induced memory impairment in mice using the Morris water maze and passive avoidance test. Moreover, we determined a possible mechanism of the cognitive-enhancing effect involving AChE activity and BD...